Giant axonal neuropathy—a generalized disorder of cytoplasmic microfilament formation
JW Prineas, RA Ouvrier, RG Wright… - … of Neuropathology & …, 1976 - academic.oup.com
JW Prineas, RA Ouvrier, RG Wright, JC Walsh, JG McLeod
Journal of Neuropathology & Experimental Neurology, 1976•academic.oup.comLight and electron microscopy of a sural nerve biopsy obtained from a patient with giant
axonal neuropathy revealed the presence of numerous axonal spheroids which were
composed chiefly of neurofilaments. Large, discrete masses of cytoplasmic microfilaments
were also observed in endoneurial fibroblasts, endothelial cells, Schwann cells, perineurial
cells and cultured skin fibroblasts. Neuronal degeneration in giant axonal neuropathy
appears to be part of a generalized disorder of cytoplasmic microfilament formation.
axonal neuropathy revealed the presence of numerous axonal spheroids which were
composed chiefly of neurofilaments. Large, discrete masses of cytoplasmic microfilaments
were also observed in endoneurial fibroblasts, endothelial cells, Schwann cells, perineurial
cells and cultured skin fibroblasts. Neuronal degeneration in giant axonal neuropathy
appears to be part of a generalized disorder of cytoplasmic microfilament formation.
Abstract
Light and electron microscopy of a sural nerve biopsy obtained from a patient with giant axonal neuropathy revealed the presence of numerous axonal spheroids which were composed chiefly of neurofilaments. Large, discrete masses of cytoplasmic microfilaments were also observed in endoneurial fibroblasts, endothelial cells, Schwann cells, perineurial cells and cultured skin fibroblasts. Neuronal degeneration in giant axonal neuropathy appears to be part of a generalized disorder of cytoplasmic microfilament formation.
Oxford University Press