We have created transgenic mice which carry and express the gene encoding the human
NF (M) subunit. RNAase protection assays reveal that the transgene is abundantly
expressed in CNS and PNS but also, at very low levels in some non-neural tissues as well.
Although the neurospecificity of transgene transcription was absolute, we are able to detect
the protein only in neurons with immunocytochemical techniques. Glial and endothelial cells
do not contain immunoreactive materials. Interesting subtle differences in the relative level of …