[HTML][HTML] Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood
JD Trudeau, C Kelly-Smith… - The Journal of …, 2003 - Am Soc Clin Investig
The Journal of clinical investigation, 2003•Am Soc Clin Investig
Autoimmune (type 1) diabetes mellitus results from the destruction of insulin-producing
pancreatic β cells by T lymphocytes. Prediction of cell-mediated autoimmune diseases by
direct detection of autoreactive T cells in peripheral blood has proved elusive, in part
because of their low frequency and reduced avidity for peptide MHC ligands.
pancreatic β cells by T lymphocytes. Prediction of cell-mediated autoimmune diseases by
direct detection of autoreactive T cells in peripheral blood has proved elusive, in part
because of their low frequency and reduced avidity for peptide MHC ligands.
Autoimmune (type 1) diabetes mellitus results from the destruction of insulin-producing pancreatic β cells by T lymphocytes. Prediction of cell-mediated autoimmune diseases by direct detection of autoreactive T cells in peripheral blood has proved elusive, in part because of their low frequency and reduced avidity for peptide MHC ligands.
The Journal of Clinical Investigation