[HTML][HTML] Viral trigger for type 1 diabetes: pros and cons
CM Filippi, MG von Herrath - Diabetes, 2008 - ncbi.nlm.nih.gov
CM Filippi, MG von Herrath
Diabetes, 2008•ncbi.nlm.nih.govThe most popular hypothesis circulating within and beyond the scientific community is that
viral infections enhance or elicit autoimmune disorders such as type 1 diabetes. Indeed,
viruses can injure β-cells and have been isolated in pancreatic tissues from diabetic
patients. However, accumulating evidence suggests that the opposite scenario, which is
prevention or amelioration of type 1 diabetes, might be at least as common an outcome of
viral infection. Here, we discuss epidemiological and experimental evidence for the main …
viral infections enhance or elicit autoimmune disorders such as type 1 diabetes. Indeed,
viruses can injure β-cells and have been isolated in pancreatic tissues from diabetic
patients. However, accumulating evidence suggests that the opposite scenario, which is
prevention or amelioration of type 1 diabetes, might be at least as common an outcome of
viral infection. Here, we discuss epidemiological and experimental evidence for the main …
The most popular hypothesis circulating within and beyond the scientific community is that viral infections enhance or elicit autoimmune disorders such as type 1 diabetes. Indeed, viruses can injure β-cells and have been isolated in pancreatic tissues from diabetic patients. However, accumulating evidence suggests that the opposite scenario, which is prevention or amelioration of type 1 diabetes, might be at least as common an outcome of viral infection. Here, we discuss epidemiological and experimental evidence for the main mechanisms accounting for the role of viruses in type 1 diabetes to better understand the complex relationship between viral infections and autoimmune diabetes.
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