Aberrant synthesis of antibodies directed at the Fab fragment of IgA in patients with IgA nephropathies
S Jackson, RI Montgomery, BA Julian, JH Galla… - Clinical immunology and …, 1987 - Elsevier
The sera of 37 patients with IgA nephropathy (IgA NP) were assayed for levels of antibodies
specific for the Fab fragment of homologous IgA, and the values obtained were compared to
antibody levels in a panel of 26 normal volunteers. IgG antibody levels in IgA NP patients
were significantly elevated over those of the controls (P< 0.01); at the same time IgM anti-
Fab α levels were significantly decreased when compared to the control panel (P< 0.01).
There was no correlation of antibody levels of either isotype with levels of circulating …
specific for the Fab fragment of homologous IgA, and the values obtained were compared to
antibody levels in a panel of 26 normal volunteers. IgG antibody levels in IgA NP patients
were significantly elevated over those of the controls (P< 0.01); at the same time IgM anti-
Fab α levels were significantly decreased when compared to the control panel (P< 0.01).
There was no correlation of antibody levels of either isotype with levels of circulating …