Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes
BACKGROUND/AIMS: Over-expression of IL-6 has been implicated in cholangiocarcinoma
growth but the cellular mechanisms involved are unknown. Our aims were to assess the
mechanisms by which over-expression of IL-6 promotes transformed cell growth in
malignant cholangiocytes. METHODS: Stably transfected cell lines over-expressing IL-6
were derived from malignant human cholangiocytes. Transformed cell growth was assessed
by anchorage independent growth in vitro and by xenograft growth in nude mice. Expression …
growth but the cellular mechanisms involved are unknown. Our aims were to assess the
mechanisms by which over-expression of IL-6 promotes transformed cell growth in
malignant cholangiocytes. METHODS: Stably transfected cell lines over-expressing IL-6
were derived from malignant human cholangiocytes. Transformed cell growth was assessed
by anchorage independent growth in vitro and by xenograft growth in nude mice. Expression …