[PDF][PDF] Low levels of circulating invariant natural killer T cells predict poor clinical outcome in patients with head and neck squamous cell carcinoma

JW Molling, JAE Langius, JA Langendijk… - Journal of clinical …, 2007 - acfw.com.br
JW Molling, JAE Langius, JA Langendijk, CR Leemans, HJ Bontkes, HJJ van der Vliet…
Journal of clinical oncology, 2007acfw.com.br
Purpose Evading antitumor immune responses is an important aspect of the pathogenesis of
head and neck squamous cell carcinoma (HNSCC). Invariant CD1d-restricted natural killer T
(iNKT) cells play an allegedly pivotal role in such responses via transactivation of immune
effector cells. It has been reported that iNKT cells are reduced in peripheral blood of cancer
patients compared with healthy controls. Here, we investigated whether the extent of this
deficiency affected disease outcome in HNSCC patients.
Purpose
Evading antitumor immune responses is an important aspect of the pathogenesis of head and neck squamous cell carcinoma (HNSCC). Invariant CD1d-restricted natural killer T (iNKT) cells play an allegedly pivotal role in such responses via transactivation of immune effector cells. It has been reported that iNKT cells are reduced in peripheral blood of cancer patients compared with healthy controls. Here, we investigated whether the extent of this deficiency affected disease outcome in HNSCC patients.
acfw.com.br