Reduced muscle necrosis and long-term benefits in dystrophic mdx mice after cV1q (blockade of TNF) treatment
HG Radley, MJ Davies, MD Grounds - Neuromuscular Disorders, 2008 - Elsevier
Tumour necrosis factor (TNF) is a potent inflammatory cytokine that appears to exacerbate
damage of dystrophic muscle in vivo. The monoclonal murine specific antibody cV1q that
specifically neutralises murine TNF demonstrated significant anti-inflammatory effects in
dystrophic mdx mice. cV1q administration protected dystrophic skeletal myofibres against
necrosis in both young and adult mdx mice and in adult mdx mice subjected to 48h voluntary
wheel exercise. Long-term studies (up to 90 days) in voluntarily exercised mdx mice showed …
damage of dystrophic muscle in vivo. The monoclonal murine specific antibody cV1q that
specifically neutralises murine TNF demonstrated significant anti-inflammatory effects in
dystrophic mdx mice. cV1q administration protected dystrophic skeletal myofibres against
necrosis in both young and adult mdx mice and in adult mdx mice subjected to 48h voluntary
wheel exercise. Long-term studies (up to 90 days) in voluntarily exercised mdx mice showed …