[HTML][HTML] BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons
CA Harris, EM Johnson - Journal of Biological Chemistry, 2001 - ASBMB
The Bcl-2 family of proteins are key regulators of programmed cell death. A distinct subfamily
of BH3-only molecules has been identified, but their exact mechanism of action remains
unclear. Here we show that the BH3-only Bcl-2 family members, Dp5/Hrk and Bim, are
induced upstream of the Bax checkpoint in neuronal apoptosis in a manner that shows
significant dependence on JNK signaling. We also show that Dp5 and other BH3-only
proteins kill cerebellar granule neurons in a Bax-dependent manner. These studies …
of BH3-only molecules has been identified, but their exact mechanism of action remains
unclear. Here we show that the BH3-only Bcl-2 family members, Dp5/Hrk and Bim, are
induced upstream of the Bax checkpoint in neuronal apoptosis in a manner that shows
significant dependence on JNK signaling. We also show that Dp5 and other BH3-only
proteins kill cerebellar granule neurons in a Bax-dependent manner. These studies …