[HTML][HTML] 15-Deoxy-Δ12, 14-prostaglandin J2: a prostaglandin D2 metabolite generated during inflammatory processes
T Shibata, M Kondo, T Osawa, N Shibata… - Journal of Biological …, 2002 - ASBMB
Prostaglandin D 2 (PGD 2), a major cyclooxygenase product in a variety of tissues, readily
undergoes dehydration to yield the cyclopentenone-type PGs of the J 2 series, such as 15-
deoxy-Δ 12, 14-PGJ 2 (15d-PGJ 2), which have been suggested to exert anti-inflammatory
effects in vivo. Meanwhile, the mechanism of these effects is not well understood and the
natural site and the extent of its productionin vivo remain unclear. In the present study, we
raised a monoclonal antibody specific to 15d-PGJ 2 and determined its production in …
undergoes dehydration to yield the cyclopentenone-type PGs of the J 2 series, such as 15-
deoxy-Δ 12, 14-PGJ 2 (15d-PGJ 2), which have been suggested to exert anti-inflammatory
effects in vivo. Meanwhile, the mechanism of these effects is not well understood and the
natural site and the extent of its productionin vivo remain unclear. In the present study, we
raised a monoclonal antibody specific to 15d-PGJ 2 and determined its production in …