[HTML][HTML] Distinct interaction of cortivazol with the ligand binding domain confers glucocorticoid receptor specificity: cortivazol is a specific ligand for the glucocorticoid …
N Yoshikawa, Y Makino, K Okamoto, C Morimoto… - Journal of Biological …, 2002 - ASBMB
Ligand-receptor coupling is one of the important constituents of signal transduction and is
essential for physiological transmission of actions of endogenous substances including
steroid hormones. However, molecular mechanisms of the redundancy between
glucocorticoid and mineralocorticoid actions remain unknown because of complicated cross-
talk among, for example, these adrenal steroids, their cognate receptors, and target genes.
Receptor-specific ligand that can distinctly modulate target gene expression should be …
essential for physiological transmission of actions of endogenous substances including
steroid hormones. However, molecular mechanisms of the redundancy between
glucocorticoid and mineralocorticoid actions remain unknown because of complicated cross-
talk among, for example, these adrenal steroids, their cognate receptors, and target genes.
Receptor-specific ligand that can distinctly modulate target gene expression should be …