Expression of angiotensinogen mRNA and protein in angiotensin II-dependent hypertension
H Kobori, LM Harrison-Bernard… - Journal of the American …, 2001 - journals.lww.com
Chronic elevations in circulating angiotensin II (AngII) levels produce sustained
hypertension and increased intrarenal AngII contents through multiple mechanisms, which
may include sustained or increased local production of AngII. This study was designed to
test the hypothesis that chronic AngII infusion increases renal angiotensinogen mRNA and
protein levels, thus contributing to the increase in intrarenal AngII levels. AngII (80 ng/min)
was infused subcutaneously for 13 d into Sprague-Dawley rats, using osmotic minipumps …
hypertension and increased intrarenal AngII contents through multiple mechanisms, which
may include sustained or increased local production of AngII. This study was designed to
test the hypothesis that chronic AngII infusion increases renal angiotensinogen mRNA and
protein levels, thus contributing to the increase in intrarenal AngII levels. AngII (80 ng/min)
was infused subcutaneously for 13 d into Sprague-Dawley rats, using osmotic minipumps …