Anti-inflammatory renoprotective effect of clopidogrel and irbesartan in chronic renal injury
X Tu, X Chen, Y Xie, S Shi, J Wang… - Journal of the American …, 2008 - journals.lww.com
Recent evidence suggests that platelet activation and angiotensin II may each contribute to
glomerular inflammation and fibrosis. Clopidogrel inhibits platelet activation and may also
reduce inflammation. This study investigated the anti-inflammatory and renoprotective
effects of clopidogrel and irbesartan in the five-sixths nephrectomy rat model of chronic
kidney disease. After 8 wk of treatment, 24-h proteinuria, serum creatinine, and histologic
scores of glomerular sclerosis and tubulointerstitial damage were significantly lower in …
glomerular inflammation and fibrosis. Clopidogrel inhibits platelet activation and may also
reduce inflammation. This study investigated the anti-inflammatory and renoprotective
effects of clopidogrel and irbesartan in the five-sixths nephrectomy rat model of chronic
kidney disease. After 8 wk of treatment, 24-h proteinuria, serum creatinine, and histologic
scores of glomerular sclerosis and tubulointerstitial damage were significantly lower in …