Myocardial infarction enhances progressive renal damage in an experimental model for cardio-renal interaction
RPE van Dokkum, WBA Eijkelkamp… - Journal of the …, 2004 - journals.lww.com
Studied were the effects of myocardial infarction (MI) on mild renal function loss in unilateral
nephrectomized (UnX) rats. UnX was performed, followed after 1 wk by a variable MI (UnX+
MI; n= 24). Rats with only UnX (n= 15) or MI (n= 9) and double sham animals (CON, n= 15)
served as controls. Renal outcome was measured by proteinuria and plasma creatinine.
Focal glomerulosclerosis (FGS) incidence was evaluated by renal histology. Cardiac
function and systolic BP were measured. A division into small and large infarcts after UnX …
nephrectomized (UnX) rats. UnX was performed, followed after 1 wk by a variable MI (UnX+
MI; n= 24). Rats with only UnX (n= 15) or MI (n= 9) and double sham animals (CON, n= 15)
served as controls. Renal outcome was measured by proteinuria and plasma creatinine.
Focal glomerulosclerosis (FGS) incidence was evaluated by renal histology. Cardiac
function and systolic BP were measured. A division into small and large infarcts after UnX …