IL-28, IL-29 and their class II cytokine receptor IL-28R
P Sheppard, W Kindsvogel, W Xu, K Henderson… - Nature …, 2003 - nature.com
P Sheppard, W Kindsvogel, W Xu, K Henderson, S Schlutsmeyer, TE Whitmore, R Kuestner…
Nature immunology, 2003•nature.comCytokines play a critical role in modulating the innate and adaptive immune systems. Here,
we have identified from the human genomic sequence a family of three cytokines,
designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I
interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were
induced by viral infection and showed antiviral activity. However, IL-28 and IL-29 interacted
with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor β (IL-10Rβ) …
we have identified from the human genomic sequence a family of three cytokines,
designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I
interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were
induced by viral infection and showed antiviral activity. However, IL-28 and IL-29 interacted
with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor β (IL-10Rβ) …
Abstract
Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by viral infection and showed antiviral activity. However, IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor β (IL-10Rβ) and an orphan class II receptor chain, designated IL-28Rα. This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection.
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