[HTML][HTML] Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-λ1: similarities with type I interferon …
L Dumoutier, A Tounsi, T Michiels… - Journal of Biological …, 2004 - ASBMB
Interferon (IFN)-λ1,-λ2, and-λ3 are the latest members of the class II cytokine family and were
shown to have antiviral activity. Their receptor is composed of two chains, interleukin-
28R/likely interleukin or cytokine or receptor 2 (IL-28R/LICR2) and IL-10Rβ, and mediates
the tyrosine phosphorylation of STAT1, STAT2, STAT3, and STAT5. Here, we show that
activation of this receptor by IFN-λ1 can also inhibit cell proliferation and induce STAT4
phosphorylation, further extending functional similarities with type I IFNs. We used IL …
shown to have antiviral activity. Their receptor is composed of two chains, interleukin-
28R/likely interleukin or cytokine or receptor 2 (IL-28R/LICR2) and IL-10Rβ, and mediates
the tyrosine phosphorylation of STAT1, STAT2, STAT3, and STAT5. Here, we show that
activation of this receptor by IFN-λ1 can also inhibit cell proliferation and induce STAT4
phosphorylation, further extending functional similarities with type I IFNs. We used IL …
