AP-1 as a regulator of cell life and death

E Shaulian, M Karin - Nature cell biology, 2002 - nature.com
E Shaulian, M Karin
Nature cell biology, 2002nature.com
The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation,
transformation and death. Using mice and cells lacking AP-1 components, the target-genes
and molecular mechanisms mediating these processes were recently identified.
Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour
suppressors, as well as upregulation of positive cell cycle regulators. Mostly, c-Jun is a
positive regulator of cell proliferation, whereas JunB has the converse effect. The intricate …
Abstract
The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation, transformation and death. Using mice and cells lacking AP-1 components, the target-genes and molecular mechanisms mediating these processes were recently identified. Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators. Mostly, c-Jun is a positive regulator of cell proliferation, whereas JunB has the converse effect. The intricate relationships between the different Jun proteins, their activities and the mechanisms that mediate them will be discussed.
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