The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants
ZE Karanjawala, N Adachi, RA Irvine, EK Oh, D Shibata… - DNA repair, 2002 - Elsevier
There are two general pathways by which multicellular eukaryotes repair double-strand
DNA breaks (DSB): homologous recombination (HR) and nonhomologous DNA end joining
(NHEJ). All mammalian mutants in the NHEJ pathway demonstrate a lack of B and T
lymphocytes and ionizing radiation sensitivity. Among these NHEJ mutants, the DNA-PKcs
and Artemis mutants are the least severe, having no obvious phenotype other than the
general defects described above. Ku mutants have an intermediate severity with accelerated …
DNA breaks (DSB): homologous recombination (HR) and nonhomologous DNA end joining
(NHEJ). All mammalian mutants in the NHEJ pathway demonstrate a lack of B and T
lymphocytes and ionizing radiation sensitivity. Among these NHEJ mutants, the DNA-PKcs
and Artemis mutants are the least severe, having no obvious phenotype other than the
general defects described above. Ku mutants have an intermediate severity with accelerated …