Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1
Y Li, J Yang, JH Luo, S Dedhar… - Journal of the American …, 2007 - journals.lww.com
In the fibrotic kidney, tubular cells undergo epithelial-to-mesenchymal transition (EMT), a
phenotypic conversion that is characterized by sequential loss of epithelial markers and gain
of mesenchymal features. For understanding of the molecular mechanism that governs this
process, a high-throughput gene expression microarray analysis was used to identify the
critical genes in the initial phase of the TGF-β1–mediated EMT. Inhibitor of differentiation-1
(Id1), a dominant negative antagonist of the basic helix-loop-helix transcription factors, was …
phenotypic conversion that is characterized by sequential loss of epithelial markers and gain
of mesenchymal features. For understanding of the molecular mechanism that governs this
process, a high-throughput gene expression microarray analysis was used to identify the
critical genes in the initial phase of the TGF-β1–mediated EMT. Inhibitor of differentiation-1
(Id1), a dominant negative antagonist of the basic helix-loop-helix transcription factors, was …
