Matrix metalloproteinases
SL Parsons, SA Watson, PD Brown… - British Journal of …, 1997 - Wiley Online Library
SL Parsons, SA Watson, PD Brown, HM Collins, RJC Steele
British Journal of Surgery, 1997•Wiley Online LibraryAbstract Background The matrix metalloproteinases (MMPs) have a role in gastrointestinal
malignancy. This role is reviewed, with particular reference to the gelatinase subgroup of
enzymes. Methods All relevant papers derived from the Medline and Enbase databases
between 1984 and early 1996 were reviewed. Result and Conclusion There is now strong
evidence that MMPs play a major role in tumour invasion and metastasis. The development
of MMP inhibitors may lead to important new treatment for the control of malignant disease.
malignancy. This role is reviewed, with particular reference to the gelatinase subgroup of
enzymes. Methods All relevant papers derived from the Medline and Enbase databases
between 1984 and early 1996 were reviewed. Result and Conclusion There is now strong
evidence that MMPs play a major role in tumour invasion and metastasis. The development
of MMP inhibitors may lead to important new treatment for the control of malignant disease.
Abstract
Background The matrix metalloproteinases (MMPs) have a role in gastrointestinal malignancy. This role is reviewed, with particular reference to the gelatinase subgroup of enzymes.
Methods All relevant papers derived from the Medline and Enbase databases between 1984 and early 1996 were reviewed.
Result and Conclusion There is now strong evidence that MMPs play a major role in tumour invasion and metastasis. The development of MMP inhibitors may lead to important new treatment for the control of malignant disease.
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