[HTML][HTML] ADP-ribosylation factor-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin

C Zahn, A Jaschke, J Weiske, A Hommel… - Journal of biological …, 2008 - ASBMB
ADP-ribosylation factor-related protein 1 (ARFRP1) plays a specific role in Golgi function
controlling recruitment of GRIP domain proteins and ARL1 to the trans-Golgi. Deletion of the
mouse Arfrp1 gene causes embryonic lethality during early gastrulation, because epiblast
cells detach from the ectodermal cell layer and do not differentiate to mesodermal tissue.
Here we show that in Arfrp1-/-embryos E-cadherin is mistargeted to intracellular
compartments, whereas in control embryos it is present at the cell surface of …