Smad3 is key to TGF-β-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis
AB Roberts, F Tian, SDC Byfield, C Stuelten… - Cytokine & growth factor …, 2006 - Elsevier
Smads2 and 3 transduce signals of TGF-β from the cell surface to the nucleus. We used
mice with a targeted deletion of Smad3 to study the specific contributions of this signaling
pathway to pathogenic effects of TGF-β. Focusing on models involving epithelial-to-
mesenchymal transition (EMT), including injury to the lens and retina of the eye and to the
kidney, we have found that loss of Smad3 blocks EMT and attenuates development of
fibrotic sequelae. Smad3 also plays a critical role in both the tumor suppressor and pro …
mice with a targeted deletion of Smad3 to study the specific contributions of this signaling
pathway to pathogenic effects of TGF-β. Focusing on models involving epithelial-to-
mesenchymal transition (EMT), including injury to the lens and retina of the eye and to the
kidney, we have found that loss of Smad3 blocks EMT and attenuates development of
fibrotic sequelae. Smad3 also plays a critical role in both the tumor suppressor and pro …