TGF-b signaling and cancer: structural and functional consequences of mutations in Smads

A Hata, Y Shi, J Massagué - Molecular medicine today, 1998 - cell.com
Molecular medicine today, 1998cell.com
Transforming growth factor-β (TGF-β) and related cytokines control the development and
homeostasis of many tissues by regulating the expression of genes that determine cell
phenotype. Recent progress has elucidated the way in which members of the TGF-β family
initiate their signal through transmembrane receptors and transmit it to target genes via the
Smad family of signal-transducing proteins. This review describes TGF-β signaling pathways
as currently understood and mutations of the genes that encode Smads that disrupt the …
Abstract
Transforming growth factor-β (TGF-β) and related cytokines control the development and homeostasis of many tissues by regulating the expression of genes that determine cell phenotype. Recent progress has elucidated the way in which members of the TGF-β family initiate their signal through transmembrane receptors and transmit it to target genes via the Smad family of signal-transducing proteins. This review describes TGF-β signaling pathways as currently understood and mutations of the genes that encode Smads that disrupt the function of these proteins and cause various forms of cancer.
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