Molecular development of the kidney: a review of the results of gene disruption studies
JH Lipschutz - American Journal of Kidney Diseases, 1998 - ajkd.org
The kidney has been used for the last 50 years as a model system for the study of tissue
inductions and vertebrate organogenesis. While much is known about the morphologic
development of the kidney, it is only in the last few years that the molecular mechanisms
involved in these processes have begun to be identified. This is largely a result of the
identification of genes expressed during kidney development and the application of
techniques for single gene disruption. Mammalian kidney development is described, and the …
inductions and vertebrate organogenesis. While much is known about the morphologic
development of the kidney, it is only in the last few years that the molecular mechanisms
involved in these processes have begun to be identified. This is largely a result of the
identification of genes expressed during kidney development and the application of
techniques for single gene disruption. Mammalian kidney development is described, and the …