Compartment-specific expression and function of the chemokine IP-10/CXCL10 in a model of renal endothelial microvascular injury

U Panzer, OM Steinmetz, RR Reinking… - Journal of the …, 2006 - journals.lww.com
The recruitment of inflammatory cells into renal tissue, mainly T cells and monocytes, is a
typical feature of various renal diseases such as glomerulonephritis, thrombotic
angiopathies, allograft rejection, and vasculitis. T cells predominantly infiltrate the
tubulointerstitium, whereas monocytes are present in the tubulointerstitial and glomerular
compartment. Because chemokines play a pivotal role in leukocyte trafficking under
inflammatory conditions, this study investigated whether a differential expression of …