[HTML][HTML] Stoichiometric phosphorylation of cardiac ryanodine receptor on serine 2809 by calmodulin-dependent kinase II and protein kinase A
P Rodriguez, MS Bhogal, J Colyer - Journal of Biological chemistry, 2003 - ASBMB
The ryanodine receptor of cardiac muscle performs a central role in excitation-contraction
coupling. Phosphorylation of the channel on serine 2809 (in rabbit or the corresponding
serine 2808 in man) alters function in vitro, although the impact of this in vivo has not been
established. We have produced a pair of antisera to the serine 2809 phosphorylation site to
aid description of the incidence and consequence of phosphorylation of this receptor. One of
these antisera is specific for the serine 2809 phosphorylated form of the cardiac ryanodine …
coupling. Phosphorylation of the channel on serine 2809 (in rabbit or the corresponding
serine 2808 in man) alters function in vitro, although the impact of this in vivo has not been
established. We have produced a pair of antisera to the serine 2809 phosphorylation site to
aid description of the incidence and consequence of phosphorylation of this receptor. One of
these antisera is specific for the serine 2809 phosphorylated form of the cardiac ryanodine …