[HTML][HTML] Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts: role of phosphatases and response …

S Reiken, M Gaburjakova, S Guatimosim… - Journal of Biological …, 2003 - ASBMB
The cardiac ryanodine receptor/calcium release channel (RyR2) on the sarcoplasmic
reticulum (SR) comprises a macromolecular complex that includes a kinase and two
phosphatases that are bound to the channel via targeting proteins. We previously found that
the RyR2 is protein kinase A (PKA)-hyperphosphorylated in end-stage human heart failure.
Because heart failure is a progressive disease that often evolves from hypertrophy, we
analyzed the RyR2 macromolecular complex in several animal models of cardiomyopathy …