Developmental expression of the CaM kinase II isoforms: ubiquitous γ-and δ-CaM kinase II are the early isoforms and most abundant in the developing nervous …
KU Bayer, J Löhler, H Schulman, K Harbers - Molecular brain research, 1999 - Elsevier
CaM kinase II constitutes a family of multifunctional protein kinases that play a major role in
Ca2+-mediated signal transduction. As a first step in understanding their possible function in
mouse development we characterized the expression patterns of all CaM kinase II isoforms
(α, β, γ and δ) starting in prenatal development. Remarkably, only the ubiquitous γ-and δ-
CaM kinase II are expressed during early development. Their distribution suggests a special
role in the developing nervous system and in mature excitable tissues. Additionally, we …
Ca2+-mediated signal transduction. As a first step in understanding their possible function in
mouse development we characterized the expression patterns of all CaM kinase II isoforms
(α, β, γ and δ) starting in prenatal development. Remarkably, only the ubiquitous γ-and δ-
CaM kinase II are expressed during early development. Their distribution suggests a special
role in the developing nervous system and in mature excitable tissues. Additionally, we …