[HTML][HTML] Mitochondrial dynamics and apoptosis: a painful separation
DI James, JC Martinou - Developmental cell, 2008 - cell.com
DI James, JC Martinou
Developmental cell, 2008•cell.comReporting in Molecular Cell, Sheridan et al.(2008) and Breckenridge et al.(2008) show that
mitochondrial fragmentation is not required to induce cell death. Meanwhile, Yamaguchi et
al. show that proapoptotic Bcl-2 family members promote cytochrome c mobilization through
Opa1-mediated cristae remodeling. Therefore, the connection between mitochondrial
structure and apoptosis is more complex than previously imagined.
mitochondrial fragmentation is not required to induce cell death. Meanwhile, Yamaguchi et
al. show that proapoptotic Bcl-2 family members promote cytochrome c mobilization through
Opa1-mediated cristae remodeling. Therefore, the connection between mitochondrial
structure and apoptosis is more complex than previously imagined.
Reporting in Molecular Cell, Sheridan et al. (2008) and Breckenridge et al. (2008) show that mitochondrial fragmentation is not required to induce cell death. Meanwhile, Yamaguchi et al. show that proapoptotic Bcl-2 family members promote cytochrome c mobilization through Opa1-mediated cristae remodeling. Therefore, the connection between mitochondrial structure and apoptosis is more complex than previously imagined.
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