[HTML][HTML] Molecular machinery of mitochondrial fusion and fission
B Westermann - Journal of Biological Chemistry, 2008 - ASBMB
Mitochondria generate energy by oxidative phosphorylation; play a crucial role in iron-sulfur
cluster assembly; and participate in intermediary metabolism, calcium signaling, and
apoptosis. They are bounded by a double membrane and contain 800 (yeast) to 1500
(human) different proteins. Although the vast majority of mitochondrial proteins are encoded
in the nucleus and post-translationally imported into the organelle, a handful of proteins
required for respiration are encoded by the mitochondrial genome. In many eukaryotic cell …
cluster assembly; and participate in intermediary metabolism, calcium signaling, and
apoptosis. They are bounded by a double membrane and contain 800 (yeast) to 1500
(human) different proteins. Although the vast majority of mitochondrial proteins are encoded
in the nucleus and post-translationally imported into the organelle, a handful of proteins
required for respiration are encoded by the mitochondrial genome. In many eukaryotic cell …