[HTML][HTML] HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein
T Lu, JC He, Z Wang, X Feng… - Journal of biological …, 2008 - ASBMB
The ability of the human immunodeficiency virus, type 1 (HIV-1) protein Nef to induce
cytoskeleton changes in infected host cells is a key event in viral replication. In renal
podocytes, we found that Nef induced loss of stress fibers and increased lamellipodia,
pathological changes leading to proteinuria in HIV-associated nephropathy. These
morphological changes were mediated by Nef-induced Rac1 activation and RhoA inhibition.
We identified a new interaction between Nef and diaphanous interacting protein (DIP), a …
cytoskeleton changes in infected host cells is a key event in viral replication. In renal
podocytes, we found that Nef induced loss of stress fibers and increased lamellipodia,
pathological changes leading to proteinuria in HIV-associated nephropathy. These
morphological changes were mediated by Nef-induced Rac1 activation and RhoA inhibition.
We identified a new interaction between Nef and diaphanous interacting protein (DIP), a …