Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model
C Ji, C Chan, N Kaplowitz - Journal of hepatology, 2006 - Elsevier
BACKGROUND/AIMS: Alcohol-induced fatty liver is associated with induction of sterol
response element binding proteins (SREBPs), transcription factors which regulate
expression of genes of lipid synthesis. The contribution of SREBP-1c to alcohol-induced fatty
liver and injury was studied. METHODS: Wild type and SREBP1c null mice were fed alcohol
or control diet by intragastric infusion for 4 weeks. H&E and TUNEL staining, real-time PCR,
RT-PCR, and immunoblotting were applied to analyze alcohol-induced liver injury …
response element binding proteins (SREBPs), transcription factors which regulate
expression of genes of lipid synthesis. The contribution of SREBP-1c to alcohol-induced fatty
liver and injury was studied. METHODS: Wild type and SREBP1c null mice were fed alcohol
or control diet by intragastric infusion for 4 weeks. H&E and TUNEL staining, real-time PCR,
RT-PCR, and immunoblotting were applied to analyze alcohol-induced liver injury …