Nicotinic acid induces secretion of prostaglandin D2 in human macrophages: an in vitro model of the niacin flush
CD Meyers, P Liu, VS Kamanna, ML Kashyap - Atherosclerosis, 2007 - Elsevier
Nicotinic acid is a safe, broad-spectrum lipid agent shown to prevent cardiovascular
disease, yet its widespread use is limited by the prostaglandin D2 (PGD2) mediated niacin
flush. Previous research suggests that nicotinic acid-induced PGD2 secretion is mediated by
the skin, but the exact cell type remains unclear. We hypothesized that macrophages are a
source of nicotinic acid-induced PGD2 secretion and performed a series of experiments to
confirm this. Nicotinic acid (0.1–3mM) induced PGD2 secretion in cultured human …
disease, yet its widespread use is limited by the prostaglandin D2 (PGD2) mediated niacin
flush. Previous research suggests that nicotinic acid-induced PGD2 secretion is mediated by
the skin, but the exact cell type remains unclear. We hypothesized that macrophages are a
source of nicotinic acid-induced PGD2 secretion and performed a series of experiments to
confirm this. Nicotinic acid (0.1–3mM) induced PGD2 secretion in cultured human …