[HTML][HTML] Distinct β-arrestin-and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation

D Gesty-Palmer, M Chen, E Reiter, S Ahn… - Journal of Biological …, 2006 - ASBMB
Parathyroid hormone (PTH) regulates calcium homeostasis via the type I PTH/PTH-related
peptide (PTH/PTHrP) receptor (PTH1R). The purpose of the present study was to identify the
contributions of distinct signaling mechanisms to PTH-stimulated activation of the mitogen-
activated protein kinases (MAPK) ERK1/2. In Human embryonic kidney 293 (HEK293) cells
transiently transfected with hPTH1R, PTH stimulated a robust increase in ERK activity. The
time course of ERK1/2 activation was biphasic with an early peak at 10 min and a later …