Long-term peritoneal dialysis is limited by physiologic changes in the peritoneum that lead
to ultrafiltration failure. To determine the role of profibrotic cytokines in the alteration of
peritoneal transport, a rodent model of transforming growth factor-β (TGF-β)-mediated
peritoneal fibrosis was established. An adenoviral vector driving the active form of TGF-β1
(AdTGFβ1) was administered intraperitoneally, and peritoneal structure and function were
evaluated for 28 d after infection. Seven days after AdTGFβ1 infection, thickening of the …