Natural killer cell activation in mice and men: different triggers for similar weapons?
F Colucci, JP Di Santo, PJ Leibson - Nature immunology, 2002 - nature.com
F Colucci, JP Di Santo, PJ Leibson
Nature immunology, 2002•nature.comThe signaling pathways that regulate B and T lymphocytes are remarkably conserved
between humans and mice. However, recent evidence suggests that the pathways
regulating natural killer (NK) cell activation may actually differ between these two species.
We discuss the controversies in the field and propose that this divergence could be
deceptive: despite some clear differences between human and mouse NK cell receptors, the
many ways of activating NK cells and their functions may well be conserved.
between humans and mice. However, recent evidence suggests that the pathways
regulating natural killer (NK) cell activation may actually differ between these two species.
We discuss the controversies in the field and propose that this divergence could be
deceptive: despite some clear differences between human and mouse NK cell receptors, the
many ways of activating NK cells and their functions may well be conserved.
Abstract
The signaling pathways that regulate B and T lymphocytes are remarkably conserved between humans and mice. However, recent evidence suggests that the pathways regulating natural killer (NK) cell activation may actually differ between these two species. We discuss the controversies in the field and propose that this divergence could be deceptive: despite some clear differences between human and mouse NK cell receptors, the many ways of activating NK cells and their functions may well be conserved.
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