The complex balance between the pro-activating and regulatory influences of the
complement system can affect the pathogenesis of immune complex-mediated
glomerulonephritis (ICGN). Key complement regulatory proteins include decay accelerating
factor (DAF) and CD59, which inhibit C3 activation and C5b-9 generation, respectively. Both
are glycosylphosphatidylinositol-linked cell membrane proteins, which are widely distributed
in humans and mice. Chronic serum sickness induced by daily immunization with horse …