[HTML][HTML] Caspase activation involves the formation of the aposome, a large (∼ 700 kDa) caspase-activating complex
K Cain, DG Brown, C Langlais, GM Cohen - Journal of Biological Chemistry, 1999 - ASBMB
In mammals, apoptotic protease-activating factor 1 (Apaf-1), cytochrome c, and dATP
activate caspase-9, which initiates the postmitochondrial-mediated caspase cascade by
proteolytic cleavage/activation of effector caspases to form active∼ 60-kDa heterotetramers.
We now demonstrate that activation of caspases either in apoptotic cells or following dATP
activation of cell lysates results in the formation of two large but different sized protein
complexes, the" aposome" and the" microaposome". Surprisingly, most of the DEVDase …
activate caspase-9, which initiates the postmitochondrial-mediated caspase cascade by
proteolytic cleavage/activation of effector caspases to form active∼ 60-kDa heterotetramers.
We now demonstrate that activation of caspases either in apoptotic cells or following dATP
activation of cell lysates results in the formation of two large but different sized protein
complexes, the" aposome" and the" microaposome". Surprisingly, most of the DEVDase …