Estrogen receptor β in prostate cancer: brake pedal or accelerator?

S Signoretti, M Loda - The American journal of pathology, 2001 - ASIP
Estrogens, via the interaction with their receptors, play important roles in the control of
cellular growth and differentiation. Specifically, estrogens regulate the growth and
development of the mammary gland in embryogenesis as well as in pre-and postpubertal
periods, and of ovarian follicles during the reproductive cycle. 1 Importantly, estrogens are
known to play a role in the development of the male reproductive system as well. 2 The
effects of estrogens on prostate epithelium are still primarily unknown although estrogens …