[HTML][HTML] DNA damage induces p53-dependent BRCA1 nuclear export
Z Feng, L Kachnic, J Zhang, SN Powell, F Xia - Journal of Biological …, 2004 - ASBMB
The tumor suppressor gene BRCA1 plays an important role in the response to DNA
damage. BRCA1 function is regulated by a variety of mechanisms including transcriptional
control, phosphorylation, and protein-protein interactions. Recent studies have shown that
BRCA1 is a nuclear-cytoplasmic shuttle protein. Its subcellular localization is controlled by a
nuclear localization signal-mediated nuclear import via the importin receptor pathway and a
nuclear export signal-facilitated nuclear export through a CRM1-dependent pathway. Using …
damage. BRCA1 function is regulated by a variety of mechanisms including transcriptional
control, phosphorylation, and protein-protein interactions. Recent studies have shown that
BRCA1 is a nuclear-cytoplasmic shuttle protein. Its subcellular localization is controlled by a
nuclear localization signal-mediated nuclear import via the importin receptor pathway and a
nuclear export signal-facilitated nuclear export through a CRM1-dependent pathway. Using …