[HTML][HTML] Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression: a prominent role in neuroprotection against excitotoxicity
RW Chen, DM Chuang - Journal of Biological Chemistry, 1999 - ASBMB
This study was undertaken to investigate the molecular mechanisms underlying the
neuroprotective actions of lithium against glutamate excitotoxicity with a focus on the role of
proapoptotic and antiapoptotic genes. Long term, but not acute, treatment of cultured
cerebellar granule cells with LiCl induces a concentration-dependent decrease in mRNA
and protein levels of proapoptotic p53 and Bax; conversely, mRNA and protein levels of
cytoprotective Bcl-2 are remarkably increased. The ratios of Bcl-2/Bax protein levels …
neuroprotective actions of lithium against glutamate excitotoxicity with a focus on the role of
proapoptotic and antiapoptotic genes. Long term, but not acute, treatment of cultured
cerebellar granule cells with LiCl induces a concentration-dependent decrease in mRNA
and protein levels of proapoptotic p53 and Bax; conversely, mRNA and protein levels of
cytoprotective Bcl-2 are remarkably increased. The ratios of Bcl-2/Bax protein levels …
