Recent dramatic decreases in acquired immunodeficiency syndrome–related mortality are
largely due to the introduction of highly active antiretroviral therapy (HAART). Although
immune restoration due to suppression of human immunodeficiency virus (HIV) replication is
a critical determinant of these trends, the magnitude of immune restoration seen after
treatment with HAART varies substantially among treated persons and is generally
incomplete. Nonetheless, even partial immune restoration is sufficient to provide protection …