The INK4a/ARF network in tumour suppression
CJ Sherr - Nature reviews Molecular cell biology, 2001 - nature.com
CJ Sherr
Nature reviews Molecular cell biology, 2001•nature.comThe retinoblastoma protein (RB) and p53 transcription factor are regulated by two distinct
proteins that are encoded by the INK4a/ARF locus. Genes encoding these four tumour
suppressors are disabled, either in whole or in part, in most human cancers. A complex
signalling network that interconnects the activities of RB and p53 monitors oncogenic stimuli
to provide a cell-autonomous mode of tumour surveillance.
proteins that are encoded by the INK4a/ARF locus. Genes encoding these four tumour
suppressors are disabled, either in whole or in part, in most human cancers. A complex
signalling network that interconnects the activities of RB and p53 monitors oncogenic stimuli
to provide a cell-autonomous mode of tumour surveillance.
Abstract
The retinoblastoma protein (RB) and p53 transcription factor are regulated by two distinct proteins that are encoded by the INK4a/ARF locus. Genes encoding these four tumour suppressors are disabled, either in whole or in part, in most human cancers. A complex signalling network that interconnects the activities of RB and p53 monitors oncogenic stimuli to provide a cell-autonomous mode of tumour surveillance.
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