Identification of genes differentially expressed by prematurely fused human sutures using a novel in vivo–in vitro approach
AK Coussens, IP Hughes, CR Wilkinson, CP Morris… - Differentiation, 2008 - Elsevier
Craniosynostosis is the premature fusion of calvarial sutures. It results from abnormal
differentiation or proliferation of cells within the osteogenic fronts of growing calvarial bones.
To date, research has focused on animal models and in vitro organ and tissue culture to
determine the molecular mechanisms controlling calvarial suture morphogenesis. Here, we
test a new, in vivo–in vitro approach based on the hypothesis that calvarial suture cells
passaged in minimal medium exhibit a stable gene expression profile similar to …
differentiation or proliferation of cells within the osteogenic fronts of growing calvarial bones.
To date, research has focused on animal models and in vitro organ and tissue culture to
determine the molecular mechanisms controlling calvarial suture morphogenesis. Here, we
test a new, in vivo–in vitro approach based on the hypothesis that calvarial suture cells
passaged in minimal medium exhibit a stable gene expression profile similar to …