[HTML][HTML] Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions inde novo methylation
Promoter region CpG island methylation is associated with tumor suppressor gene silencing
in neoplasia. GenBank sequence analyses revealed that a number of CpG islands are
juxtaposed to multiple Alu repeats, which have been proposed as" de novo methylation
centers." These islands also contain multiple Sp1 elements located upstream and
downstream of transcription start, which have been shown to protect CpG islands from
methylation. We mapped the methylation patterns of the E-cadherin (E-cad) and von Hippel …
in neoplasia. GenBank sequence analyses revealed that a number of CpG islands are
juxtaposed to multiple Alu repeats, which have been proposed as" de novo methylation
centers." These islands also contain multiple Sp1 elements located upstream and
downstream of transcription start, which have been shown to protect CpG islands from
methylation. We mapped the methylation patterns of the E-cadherin (E-cad) and von Hippel …