The many ways of Wnt in cancer
P Polakis - Current opinion in genetics & development, 2007 - Elsevier
P Polakis
Current opinion in genetics & development, 2007•ElsevierMore than 20 years ago, the oncogenicity of a Wnt ligand was revealed in a series of
experiments originating with random proviral integration in mice. The significance of Wnt
signaling in human cancer has since been buttressed by the identification of mutations in
genes coding for the Wnt pathway components Axin, APC, and β-catenin. This review
summarizes the reported genetic defects in the Wnt pathway, with an emphasis on their
functional contribution to human tumor progression.
experiments originating with random proviral integration in mice. The significance of Wnt
signaling in human cancer has since been buttressed by the identification of mutations in
genes coding for the Wnt pathway components Axin, APC, and β-catenin. This review
summarizes the reported genetic defects in the Wnt pathway, with an emphasis on their
functional contribution to human tumor progression.
More than 20 years ago, the oncogenicity of a Wnt ligand was revealed in a series of experiments originating with random proviral integration in mice. The significance of Wnt signaling in human cancer has since been buttressed by the identification of mutations in genes coding for the Wnt pathway components Axin, APC, and β-catenin. This review summarizes the reported genetic defects in the Wnt pathway, with an emphasis on their functional contribution to human tumor progression.
Elsevier