[HTML][HTML] TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption

T Voets, B Nilius, S Hoefs, AWCM van der Kemp… - Journal of Biological …, 2004 - ASBMB
Mg 2+ is an essential ion involved in a multitude of physiological and biochemical processes
and a major constituent of bone tissue. Mg 2+ homeostasis in mammals depends on the
equilibrium between intestinal Mg 2+ absorption and renal Mg 2+ excretion, but little is
known about the molecular nature of the proteins involved in the transepithelial transport of
Mg 2+ in these organs. Recently, it was shown that patients with mutations in TRPM6, a
member of the transient receptor potential family of cation channels, suffer from …