Structure of the voltage‐dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous systems.
A Baumann, A Grupe, A Ackermann, O Pongs - The EMBO Journal, 1988 - embopress.org
A Baumann, A Grupe, A Ackermann, O Pongs
The EMBO Journal, 1988•embopress.orgVoltage‐sensitive potassium channels are found in vertebrate and invertebrate central
nervous systems. We have isolated a rat brain cDNA by cross‐hybridization with a probe of
the Drosophila Shaker gene complex. Structural conservation of domains of the deduced
protein indicate that the rat brain cDNA encodes a voltage‐sensitive potassium channel. Of
the deduced amino acid sequence, 82% is homologous to the Drosophila Shaker protein
indicating that voltage‐sensitive potassium channels have been highly conserved during …
nervous systems. We have isolated a rat brain cDNA by cross‐hybridization with a probe of
the Drosophila Shaker gene complex. Structural conservation of domains of the deduced
protein indicate that the rat brain cDNA encodes a voltage‐sensitive potassium channel. Of
the deduced amino acid sequence, 82% is homologous to the Drosophila Shaker protein
indicating that voltage‐sensitive potassium channels have been highly conserved during …
Voltage‐sensitive potassium channels are found in vertebrate and invertebrate central nervous systems. We have isolated a rat brain cDNA by cross‐hybridization with a probe of the Drosophila Shaker gene complex. Structural conservation of domains of the deduced protein indicate that the rat brain cDNA encodes a voltage‐sensitive potassium channel. Of the deduced amino acid sequence, 82% is homologous to the Drosophila Shaker protein indicating that voltage‐sensitive potassium channels have been highly conserved during evolution. Selective pressure was highest on sequences facing the intracellular side and on proposed transmembrane segments S4‐S6, suggesting that these domains are crucial for voltage‐dependent potassium channel function. The corresponding rat mRNA apparently belongs to a family of mRNA molecules which are preferentially expressed in the central nervous system.
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