[HTML][HTML] Regulation of angiogenesis by glycogen synthase kinase-3β
HS Kim, C Skurk, SR Thomas, A Bialik, T Suhara… - Journal of Biological …, 2002 - ASBMB
Glycogen synthase kinase-3β (GSK3β) plays important roles in metabolism, embryonic
development, and tumorigenesis. Here we investigated the role of GSK3β signaling in
vascular biology by examining its function in endothelial cells (ECs). In EC, the regulatory
phosphorylation of GSK3β was found to be under the control of phosphoinositide 3-kinase-,
MAPK-, and protein kinase A-dependent signaling pathways. The transduction of a
nonphosphorylatable constitutively active mutant of GSKβ promoted apoptosis under the …
development, and tumorigenesis. Here we investigated the role of GSK3β signaling in
vascular biology by examining its function in endothelial cells (ECs). In EC, the regulatory
phosphorylation of GSK3β was found to be under the control of phosphoinositide 3-kinase-,
MAPK-, and protein kinase A-dependent signaling pathways. The transduction of a
nonphosphorylatable constitutively active mutant of GSKβ promoted apoptosis under the …