Sterol regulatory element-binding protein-1 as a dominant transcription factor for gene regulation of lipogenic enzymes in the liver
H Shimano - Trends in cardiovascular medicine, 2000 - Elsevier
Sterol regulatory element-binding proteins (SREBPs) are basic helix-loop-helix (bHLH) type
transcription factors that control expression of genes involved in biosynthesis of cholesterol
and fatty acids. Dietary studies with normal, transgenic, and knockout mice have established
SREBP-1 as a dominant transcription factor regulating gene expression of lipogenic enzyme
in the liver. Polyunsaturated fatty acids inhibit hepatic lipogenic enzymes through
suppressing SREBP-1. Whereas SREBP-2 exerts sterol regulation through cleavage of the …
transcription factors that control expression of genes involved in biosynthesis of cholesterol
and fatty acids. Dietary studies with normal, transgenic, and knockout mice have established
SREBP-1 as a dominant transcription factor regulating gene expression of lipogenic enzyme
in the liver. Polyunsaturated fatty acids inhibit hepatic lipogenic enzymes through
suppressing SREBP-1. Whereas SREBP-2 exerts sterol regulation through cleavage of the …